Purified unitary kainate/alpha-amino-3-hydroxy-5-methylisooxazole-propionate (AMPA) and kainate/AMPA/N-methyl-D-aspartate receptors with interchangeable subunits.
نویسندگان
چکیده
منابع مشابه
Functional reconstitution of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors from rat brain.
Glutamate receptors belonging to the subclass specifically activated by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) were solubilized from rat forebrain membranes with Triton X-100 and partially purified through a series of three chromatographic steps. Specific [3H]AMPA binding increased 30-60-fold during the isolation procedure. A protein band recognized by antibodies agains...
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Positive modulators of the excitatory amino acid receptor a-Amino-3hydroxy-5-methyl-4-isoxazole Propionate (AMPA) has been shown to enhance memory and learning tasks performed by rodents and by human subjects. A new class of AMPA receptor modulators has been recently synthesized. These compounds belong to the class of organic nitrate ester of the nitroglycerine family and are designated GT-2 1-...
متن کاملALS amyotrophic lateral sclerosis AMPA α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid GABA γ-aminobutyric acid NMDA N-methyl-D-aspartate PD Parkinson’s disease
Addresses *Howard Hughes Medical Institute and Baylor College of Medicine, One Baylor Plaza MS225, Houston, Texas 77030, USA; e-mail: [email protected] †Laboratory of Genetics, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA; e-mail: [email protected] ‡Department of Neurology, Washington University School of Medicine, Center for the Study of Nervous System Injur...
متن کاملSubunit Dependencies of N-Methyl-D-aspartate (NMDA) Receptor-Induced -Amino-3-hydroxy-5-methyl-4- isoxazolepropionic Acid (AMPA) Receptor Internalization
N-Methyl-D-aspartate (NMDA) receptor (NMDAR) activity regulates the net number of -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPAR) at the cell surface by modulating the balance between AMPAR membrane insertion and endocytosis. In this study, we addressed the role of NMDAR subtypes and of NMDAR-mediated Ca influx in the NMDAR-induced endocytosis of GluR2-containing AM...
متن کاملSubunit dependencies of N-methyl-D-aspartate (NMDA) receptor-induced alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization.
N-Methyl-D-aspartate (NMDA) receptor (NMDAR) activity regulates the net number of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPAR) at the cell surface by modulating the balance between AMPAR membrane insertion and endocytosis. In this study, we addressed the role of NMDAR subtypes and of NMDAR-mediated Ca2+ influx in the NMDAR-induced endocytosis of GluR2-contai...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1992
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.89.11.4806